دورية أكاديمية
Secondary giant cell glioblastoma in a multiple drug abuser - simple association or ethiopathogenic correlation?
| العنوان: | Secondary giant cell glioblastoma in a multiple drug abuser - simple association or ethiopathogenic correlation? |
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| المؤلفون: | L. Eva, M. S. Ples, M. R. Munteanu, Gabriela Florenta Dumitrescu, Nicoleta Dumitrescu, Horia Ples |
| المصدر: | Romanian Neurosurgery, Vol 33, Iss 4 (2019) |
| بيانات النشر: | London Academic Publishing, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | multiple drug abuse, psychiatric symptoms, secondary giant cell, glioblastoma, partial tumour resection, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Experimental investigations have shown that drug abuse initiates a cascade of pathophysiological events including toxic and hypoxic-ischemic injury on neurons, microglia and astrocytes, which finally lead to widespread disturbances in the brain. There are many reports about the psychiatric and neurologic effects of multiple drug abuse, but only a few clinical studies reporting possible correlation between recreational illicit drugs and gliomas. In this paper we present the case of a 40 years-old male patient, with a long history (almost ten years) of multiple drug abuse, including cocaine, heroin, marijuana, ethnobotanical drugs and nicotine, who was diagnosed and surgically treated for a supratentorial secondary giant cell glioblastoma (sgcGB) developed in a diffuse astrocytoma NOS. Depending on the type of the illicit drug used by the patient and the moment of life he used them, the morphological features identified in the histological samples of our patient confirmed the gliomagenesis effect of chronic multiple drug abuse, but also its inhibitory effects on tumour cells growth. This was due to the fact that although the tumour was large in size and caused brain sub-falcine herniation, the patient reported the onset of seizures only late in the evolution. In conclusion, the diagnosis of a brain tumour should take into consideration not only patient's clinical and imaging data, but also his lifestyle, especially his addiction to recreational drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1220-8841 2344-4959 |
| Relation: | https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/1269; https://doaj.org/toc/1220-8841; https://doaj.org/toc/2344-4959 |
| DOI: | 10.33962/roneuro-2019-063 |
| URL الوصول: | https://doaj.org/article/db1c07f0fa48418fbe234667d6ca5f88 |
| رقم الأكسشن: | edsdoj.b1c07f0fa48418fbe234667d6ca5f88 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12208841 23444959 |
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| DOI: | 10.33962/roneuro-2019-063 |