دورية أكاديمية
Alteration of plasma metabolites associated with chemoradiosensitivity in esophageal squamous cell carcinoma via untargeted metabolomics approach
| العنوان: | Alteration of plasma metabolites associated with chemoradiosensitivity in esophageal squamous cell carcinoma via untargeted metabolomics approach |
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| المؤلفون: | Yaowen Zhang, Jianpo Wang, Ningtao Dai, Peng Han, Jian Li, Jiangman Zhao, Weilan Yuan, Jiahuan Zhou, Fuyou Zhou |
| المصدر: | BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Chemoradiosensitivity, Esophageal squamous cell carcinoma, Metabolomics, Neoadjuvant therapy, Untargeted metabolomics analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background To investigate the differences in plasma metabolomic characteristics between pathological complete response (pCR) and non-pCR patients and identify biomarker candidates for predicting the response to neoadjuvant chemoradiotherapy (nCRT) in esophageal squamous cell carcinoma (ESCC). Methods A total of 46 ESCC patients were included in this study. Gas chromatography time-of- flight mass spectrometry (GC-TOF/MS) technology was applied to detect the plasma samples collected before nCRT via untargeted metabolomics analysis. Results Five differentially expressed metabolites (out of 109) was found in plasma between pCR and non-pCR groups. Compared with non-pCR group, isocitric acid (p = 0.0129), linoleic acid (p = 0.0137), citric acid (p = 0.0473) were upregulated, while L-histidine (p = 0.0155), 3′4 dihydroxyhydrocinnamic acid (p = 0.0339) were downregulated in the pCR plasma samples. Pathway analyses unveiled that citrate cycle (TCA cycle), glyoxylate and dicarboxylate metabolic pathway were associated with ESCC chemoradiosensitivity. Conclusion The present study provided supporting evidence that GC-TOF/MS based metabolomics approach allowed identification of metabolite differences between pCR and non-pCR patients in plasma levels, and the systemic metabolic status of patients may reflect the response of ESCC patient to neoadjuvant chemoradiotherapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2407 34481966 |
| Relation: | http://link.springer.com/article/10.1186/s12885-020-07336-9; https://doaj.org/toc/1471-2407 |
| DOI: | 10.1186/s12885-020-07336-9 |
| URL الوصول: | https://doaj.org/article/b1c1b8fc61a34481966262fc25c8557d |
| رقم الأكسشن: | edsdoj.b1c1b8fc61a34481966262fc25c8557d |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712407 34481966 |
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| DOI: | 10.1186/s12885-020-07336-9 |