دورية أكاديمية
IRF8: Mechanism of Action and Health Implications
| العنوان: | IRF8: Mechanism of Action and Health Implications |
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| المؤلفون: | Hannah R. Moorman, Yazmin Reategui, Dakota B. Poschel, Kebin Liu |
| المصدر: | Cells, Vol 11, Iss 17, p 2630 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | IRF8, myeloid cells, OPN, MDSCs, immunotherapy, Cytology, QH573-671 |
| الوصف: | Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b+Gr1+ immature myeloid cells (IMCs), particularly the CD11b+Ly6Chi/+Ly6G− polymorphonuclear myeloid-derived suppressor cell-like cells (PMN-MDSCs). Under pathological conditions such as cancer, Irf8 is silenced by its promoter DNA hypermethylation, resulting in accumulation of PMN-MDSCs and CD11b+ Ly6G+Ly6Clo monocytic MDSCs (M-MDSCs) in mice. IRF8 is often silenced in MDSCs in human cancer patients. MDSCs are heterogeneous populations of immune suppressive cells that suppress T and NK cell activity to promote tumor immune evasion and produce growth factors to exert direct tumor-promoting activity. Emerging experimental data reveals that IRF8 is also expressed in non-hematopoietic cells. Epithelial cell-expressed IRF8 regulates apoptosis and represses Osteopontin (OPN). Human tumor cells may use the IRF8 promoter DNA methylation as a mechanism to repress IRF8 expression to advance cancer through acquiring apoptosis resistance and OPN up-regulation. Elevated OPN engages CD44 to suppress T cell activation and promote tumor cell stemness to advance cancer. IRF8 thus is a transcription factor that regulates both the immune and non-immune components in human health and diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11172630 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/11/17/2630; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells11172630 |
| URL الوصول: | https://doaj.org/article/b1dd1f8f30b74575b3e72a6913ce9707 |
| رقم الأكسشن: | edsdoj.b1dd1f8f30b74575b3e72a6913ce9707 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11172630 20734409 |
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| DOI: | 10.3390/cells11172630 |