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Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism

التفاصيل البيبلوغرافية
العنوان: Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism
المؤلفون: Jeannine A. Frei, Cheryl J. Brandenburg, Jonathan E. Nestor, Didier M. Hodzic, Celine Plachez, Helen McNeill, Derek M. Dykxhoorn, Michael W. Nestor, Gene J. Blatt, Yu-Chih Lin
المصدر: Biology Open, Vol 10, Iss 6 (2021)
بيانات النشر: The Company of Biologists, 2021.
سنة النشر: 2021
المجموعة: LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: fat1, cadherin, cerebellum, granule cells, autism, neural precursor cells, Science, Biology (General), QH301-705.5
الوصف: Genetic studies have linked FAT1 (FAT atypical cadherin 1) with autism spectrum disorder (ASD); however, the role that FAT1 plays in ASD remains unknown. In mice, the function of Fat1 has been primarily implicated in embryonic nervous system development with less known about its role in postnatal development. We show for the first time that FAT1 protein is expressed in mouse postnatal brains and is enriched in the cerebellum, where it localizes to granule neurons and Golgi cells in the granule layer, as well as inhibitory neurons in the molecular layer. Furthermore, subcellular characterization revealed FAT1 localization in neurites and soma of granule neurons, as well as being present in the synaptic plasma membrane and postsynaptic densities. Interestingly, FAT1 expression was decreased in induced pluripotent stem cell (iPSC)-derived neural precursor cells (NPCs) from individuals with ASD. These findings suggest a novel role for FAT1 in postnatal development and may be particularly important for cerebellum function. As the cerebellum is one of the vulnerable brain regions in ASD, our study warrants further investigation of FAT1 in the disease etiology.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2046-6390
Relation: http://bio.biologists.org/content/10/6/bio056457; https://doaj.org/toc/2046-6390
DOI: 10.1242/bio.056457
URL الوصول: https://doaj.org/article/b1e950df02b1419bbe7fff1784d77123
رقم الأكسشن: edsdoj.b1e950df02b1419bbe7fff1784d77123
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20466390
DOI:10.1242/bio.056457