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High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation

التفاصيل البيبلوغرافية
العنوان: High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation
المؤلفون: Subin Lim, Soon Jun Hong, Ju Hyeon Kim, Jung-Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Byeong-Keuk Kim, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Young-Hoon Jeong, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Do-Sun Lim, PTRG Investigators
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Stent thrombosis (ST) is a fatal complication after percutaneous coronary intervention (PCI). The association between P2Y12 reaction unit (PRU) level and stent thrombosis occurrence remains unclear. Based on the multicenter, observational PTRG-DES (Platelet function and genoType-Related long-term proGnosis in DES-treated patients) registry of patients with drug-eluting stents (DES) implantation, a total of 11,714 patients with PRU values were analyzed. We sought to identify the predictors of early stent thrombosis (EST) and compared the primary outcome, a composite of cardiac death, myocardial infarction, and revascularization, between EST and non-EST groups. EST, defined as definite ST within 1 month after index PCI, occurred in 51 patients. PRU values were significantly higher in the EST group (263.5 ± 70.8 vs. 217.5 ± 78.7, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-50920-9
URL الوصول: https://doaj.org/article/b207409193d04020ba8773de264279ed
رقم الأكسشن: edsdoj.b207409193d04020ba8773de264279ed
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-023-50920-9