دورية أكاديمية
Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
| العنوان: | Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment |
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| المؤلفون: | Saulo Gomes de Oliveira, Ilana Brito Ferraz de Souza, Taynan da Silva Constantino, Paula Carolina Valença Silva, Elker Lene Santos de Lima, Maria Tereza Cartaxo Muniz, Ana Lúcia Coutinho Domingues |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2020) |
| بيانات النشر: | Sociedade Brasileira de Medicina Tropical (SBMT), 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine |
| مصطلحات موضوعية: | Schistosomiasis, Periportal fibrosis, Mannose-binding lectin, Arctic medicine. Tropical medicine, RC955-962 |
| الوصف: | Abstract INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-9849 0037-8682 02765241 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100608&tlng=en; https://doaj.org/toc/1678-9849 |
| DOI: | 10.1590/0037-8682-0145-2020 |
| URL الوصول: | https://doaj.org/article/b28a0276524147c491166c8b9c496922 |
| رقم الأكسشن: | edsdoj.b28a0276524147c491166c8b9c496922 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16789849 00378682 02765241 |
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| DOI: | 10.1590/0037-8682-0145-2020 |