دورية أكاديمية
Hydrogel platform capable of molecularly resolved pulling on cells for mechanotransduction
| العنوان: | Hydrogel platform capable of molecularly resolved pulling on cells for mechanotransduction |
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| المؤلفون: | Nan Cheng, Yile Zhang, Yukai Wu, Bohan Li, Hong Wang, Shaojie Chen, Peng Zhao, Jiaxi Cui, Xiaoqin Shen, Xingjun Zhu, Yijun Zheng |
| المصدر: | Materials Today Bio, Vol 17, Iss , Pp 100476- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Hydrogel platform, Near-infrared light, Macromolecular actuator, Cell-ECM interaction, Mechanotransduction, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The active forces exerted from the extracellular matrix (ECM) to mechanoreceptors have crucial impact on many cell functions and disease development. However, our understanding of the underlying mechanisms is held back due to the lack of ECM mimicking platform able to apply molecularly resolved forces to cells. Herein, we present novel hydrogel platform capable of generate pN range forces to specific cellular receptors, at molecular scale. This capability was achieved through near-infrared (NIR) light regulated macromolecular actuators functionalized within the platform. This platform enables us to reveal cell responses to molecularly resolved forces under controlled magnitude (150–400 pN) and frequency (up to 100 Hz) on matrix with varied stiffness. We find the stiffness of the matrix has a large influence on the applied force transduction to cells. This versatile platform holds the potential for establishing correlation between receptor signaling pathways and cellular responses closer to physiological conditions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006422002745; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2022.100476 |
| URL الوصول: | https://doaj.org/article/cb2c1f247faf45cdb1215844ce70400b |
| رقم الأكسشن: | edsdoj.b2c1f247faf45cdb1215844ce70400b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2022.100476 |