دورية أكاديمية
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice
| العنوان: | Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
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| المؤلفون: | Park Won-Hwan, Kang Eun-Young, Seo Su-Hyun, Chung Ill-Min, Moon Hyung-In |
| المصدر: | Malaria Journal, Vol 8, Iss 1, p 151 (2009) |
| بيانات النشر: | BMC, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Background Petroleum ether extracts of Viola websteri Hemsl (Violaceae) were reported to have anti-plasmodial activity against Plasmodium falciparum in vitro, with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA). Methods The schizontocidal activity of 6-SA on early Plasmodium berghei infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD50) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke. Results In the present study, 6-SA was found to have anti-malarial activity in vivo, when tested against P. berghei in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day). Conclusion 6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2875 49291254 |
| Relation: | http://www.malariajournal.com/content/8/1/151; https://doaj.org/toc/1475-2875 |
| DOI: | 10.1186/1475-2875-8-151 |
| URL الوصول: | https://doaj.org/article/b2c5d49291254ad4a493f4a6f1341e93 |
| رقم الأكسشن: | edsdoj.b2c5d49291254ad4a493f4a6f1341e93 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752875 49291254 |
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| DOI: | 10.1186/1475-2875-8-151 |