دورية أكاديمية

The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics

التفاصيل البيبلوغرافية
العنوان: The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics
المؤلفون: Hyosun Tak, Seongho Cha, Youlim Hong, Myeongwoo Jung, Seungyeon Ryu, Sukyoung Han, Seung Min Jeong, Wook Kim, Eun Kyung Lee
المصدر: Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
بيانات النشر: Nature Publishing Group, 2024.
سنة النشر: 2024
المجموعة: LCC:Cytology
مصطلحات موضوعية: Cytology, QH573-671
الوصف: Abstract Senescent cells exhibit a diverse spectrum of changes in their morphology, proliferative capacity, senescence-associated secretory phenotype (SASP) production, and mitochondrial homeostasis. These cells often manifest with elongated mitochondria, a hallmark of cellular senescence. However, the precise regulatory mechanisms orchestrating this phenomenon remain predominantly unexplored. In this study, we provide compelling evidence for decreases in TIA-1, a pivotal regulator of mitochondrial dynamics, in models of both replicative senescence and ionizing radiation (IR)-induced senescence. The downregulation of TIA-1 was determined to trigger mitochondrial elongation and enhance the expression of senescence-associated β-galactosidase, a marker of cellular senescence, in human foreskin fibroblast HS27 cells and human keratinocyte HaCaT cells. Conversely, the overexpression of TIA-1 mitigated IR-induced cellular senescence. Notably, we identified the miR-30-5p family as a novel factor regulating TIA-1 expression. Augmented expression of the miR-30-5p family was responsible for driving mitochondrial elongation and promoting cellular senescence in response to IR. Taken together, our findings underscore the significance of the miR-30-5p/TIA-1 axis in governing mitochondrial dynamics and cellular senescence.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-4889
Relation: https://doaj.org/toc/2041-4889
DOI: 10.1038/s41419-024-06797-1
URL الوصول: https://doaj.org/article/b2d855c1574c45fbb54d081ddc88c1b1
رقم الأكسشن: edsdoj.b2d855c1574c45fbb54d081ddc88c1b1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20414889
DOI:10.1038/s41419-024-06797-1