دورية أكاديمية
Progress in Single-cell RNA Sequencing of Lung Adenocarcinoma
| العنوان: | Progress in Single-cell RNA Sequencing of Lung Adenocarcinoma |
|---|---|
| المؤلفون: | Yichu LIN, Donglai CHEN, Qifeng DING, Xuejuan ZHU, Rongying ZHU, Yongbing CHEN |
| المصدر: | Chinese Journal of Lung Cancer, Vol 24, Iss 6, Pp 434-440 (2021) |
| بيانات النشر: | Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | lung neoplasms, single-cell sequencing, drug resistance, progression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and one of the main causes of cancer-related deaths. In the past decade, with the widespread use of computed tomography (CT) in routine screening for lung cancer, the incidence of LUAD presenting as small pulmonary nodules radiologically, has increased remarkably. The mechanisms of the occurrence and progression of LUADs are complex, and the prognoses of patients with LUAD vary significantly. Although significant progress has been made in targeted therapy and immunotherapy for LUADs in recent years, the drug resistance of tumor cells has not been effectively overcome, which limits the benefits of patients. With the accomplishment of the Human Genome Project, sequencing-based genomic and transcriptomics have come into the field of clinical and scientific researches. Single-cell sequencing, as a new type of sequencing method that has captured increasing attention recently, can perform specific analysis of cell populations at single-cell level, which can reveal the unique changes of each cell type. Single-cell sequencing can also provide accurate assessment on heterogeneous stromal cells and cancer cells, which is helpful to reveal the complexity of molecular compositions and differences between non- and malignant tissues. To sum up, it is an urgent need for clinicians and basic scientists to deeply understand the pathogenesis and development of LUAD, the heterogeneity of tumor microenvironment (TME) and the mechanism of drug resistance formation through single-cell sequencing, so as to discover new therapeutic targets. In this paper, we reviewed and summarized the application and progress in single-cell sequencing of LUADs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1009-3419 1999-6187 |
| Relation: | https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2021.102.19 |
| URL الوصول: | https://doaj.org/article/cb2db61fbaab439cbefae877ce9b1646 |
| رقم الأكسشن: | edsdoj.b2db61fbaab439cbefae877ce9b1646 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10093419 19996187 |
|---|---|
| DOI: | 10.3779/j.issn.1009-3419.2021.102.19 |