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Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders.

التفاصيل البيبلوغرافية
العنوان: Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders.
المؤلفون: Jihane Pakradouni, Wilfried Le Goff, Claire Calmel, Bénédicte Antoine, Elise Villard, Eric Frisdal, Marianne Abifadel, Joan Tordjman, Christine Poitou, Dominique Bonnefont-Rousselot, Randa Bittar, Eric Bruckert, Karine Clément, Bruno Fève, Cécile Martinerie, Maryse Guérin
المصدر: PLoS ONE, Vol 8, Iss 6, p e66788 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVE:Evidence points to a founder of the multifunctional CCN family, NOV/CCN3, as a circulating molecule involved in cardiac development, vascular homeostasis and inflammation. No data are available on the relationship between plasma NOV/CCN3 levels and cardiovascular risk factors in humans. This study investigated the possible relationship between plasma NOV levels and cardiovascular risk factors in humans. METHODS:NOV levels were measured in the plasma from 594 adults with a hyperlipidemia history and/or with lipid-lowering therapy and/or a body mass index (BMI) >30 kg/m(2). Correlations were measured between NOV plasma levels and various parameters, including BMI, fat mass, and plasma triglycerides, cholesterol, glucose, and C-reactive protein. NOV expression was also evaluated in adipose tissue from obese patients and rodents and in primary cultures of adipocytes and macrophages. RESULTS:After full multivariate adjustment, we detected a strong positive correlation between plasma NOV and BMI (r = 0.36 p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3681908?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0066788
URL الوصول: https://doaj.org/article/b2e4f187d15a43ef969468e840ebe89c
رقم الأكسشن: edsdoj.b2e4f187d15a43ef969468e840ebe89c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0066788