دورية أكاديمية
An Ultra-Rapid Biosensory Point-of-Care (POC) Assay for Prostate-Specific Antigen (PSA) Detection in Human Serum
| العنوان: | An Ultra-Rapid Biosensory Point-of-Care (POC) Assay for Prostate-Specific Antigen (PSA) Detection in Human Serum |
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| المؤلفون: | Sophie Mavrikou, Georgia Moschopoulou, Athanasios Zafeirakis, Konstantina Kalogeropoulou, Georgios Giannakos, Athanasios Skevis, Spyridon Kintzios |
| المصدر: | Sensors, Vol 18, Iss 11, p 3834 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Chemical technology |
| مصطلحات موضوعية: | bioelectric recognition assay, cellular biosensor, high-throughput, immunoassay, molecular identification through membrane engineering, point-of-care, prostate cancer, prostate-specific antigen, Chemical technology, TP1-1185 |
| الوصف: | Prostate-specific antigen (PSA) is the established routine screening tool for the detection of early-stage prostate cancer. Given the laboratory-centric nature of the process, the development of a portable, ultra rapid high-throughput system for PSA screening is highly desirable. In this study, an advancedpoint-of-care system for PSA detection in human serum was developed based on a cellular biosensor where the cell membrane was modified by electroinserting a specific antibody against PSA. Thirty nine human serum samples were used for validation of this biosensory system for PSA detection. Samples were analyzed in parallel with a standard immunoradiometric assay (IRMA) and an established electrochemical immunoassay was used for comparison purposes. They were classified in three different PSA concentration ranges (0, |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8220 18113834 |
| Relation: | https://www.mdpi.com/1424-8220/18/11/3834; https://doaj.org/toc/1424-8220 |
| DOI: | 10.3390/s18113834 |
| URL الوصول: | https://doaj.org/article/b2f3049addcf4abcaa481444edea4bcf |
| رقم الأكسشن: | edsdoj.b2f3049addcf4abcaa481444edea4bcf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248220 18113834 |
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| DOI: | 10.3390/s18113834 |