دورية أكاديمية
geneshot: gene-level metagenomics identifies genome islands associated with immunotherapy response
| العنوان: | geneshot: gene-level metagenomics identifies genome islands associated with immunotherapy response |
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| المؤلفون: | Samuel S. Minot, Kevin C. Barry, Caroline Kasman, Jonathan L. Golob, Amy D. Willis |
| المصدر: | Genome Biology, Vol 22, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Genetics |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Genetics, QH426-470 |
| الوصف: | Abstract Researchers must be able to generate experimentally testable hypotheses from sequencing-based observational microbiome experiments to discover the mechanisms underlying the influence of gut microbes on human health. We describe geneshot, a novel bioinformatics tool for identifying testable hypotheses based on gene-level metagenomic analysis of WGS microbiome data. By applying geneshot to two independent previously published cohorts, we identify microbial genomic islands consistently associated with response to immune checkpoint inhibitor (ICI)-based cancer treatment in culturable type strains. The identified genomic islands are within operons involved in type II secretion, TonB-dependent transport, and bacteriophage growth. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1474-760X |
| Relation: | https://doaj.org/toc/1474-760X |
| DOI: | 10.1186/s13059-021-02355-6 |
| URL الوصول: | https://doaj.org/article/b32b0dda71424fefae1e0642ce533a53 |
| رقم الأكسشن: | edsdoj.b32b0dda71424fefae1e0642ce533a53 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1474760X |
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| DOI: | 10.1186/s13059-021-02355-6 |