دورية أكاديمية
Functional targeted therapy for glioma based on platelet membrane-coated nanogels
| العنوان: | Functional targeted therapy for glioma based on platelet membrane-coated nanogels |
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| المؤلفون: | Qin Li, Jinglan Shen, Lingling Wu, Siyun Lei, Yimin Yang, Weide Xu, Ke Hao, Yi Zhang, Fei Kong, Wei Yang, Yaling Wang, Lina Peng, Kaiqiang Li, Zhen Wang |
| المصدر: | Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-17 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Glioma, Blood–brain barrier, Biomimetic drug delivery system, Vasculogenic mimicry, Platelet membrane, Nanogel, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects the treatment of glioma. Herein, we developed a targeted biomimetic drug delivery system comprising a doxorubicin-loaded platelet membrane-coated nanogel (DOX@PNGs). The nanogels provide great redox/pH dual responsiveness, while the platelet membrane (PLTM) promotes stability and circulation time. In vitro cellular uptake and in vivo imaging experiments demonstrated that the DOX@PNGs delivery system could penetrate the BBB, target gliomas, and destruct VM. DOX@PNGs increased drug penetration and prolonged mouse survival time during the treatment of orthotopic gliomas. These results indicate this biomimetic drug delivery system to be promising for glioma treatment and may be clinically translated in the future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1868-6958 1868-6966 83942939 |
| Relation: | https://doaj.org/toc/1868-6958; https://doaj.org/toc/1868-6966 |
| DOI: | 10.1186/s12645-023-00167-w |
| URL الوصول: | https://doaj.org/article/b349944b739049dfafad839429395d6b |
| رقم الأكسشن: | edsdoj.b349944b739049dfafad839429395d6b |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 18686958 18686966 83942939 |
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| DOI: | 10.1186/s12645-023-00167-w |