دورية أكاديمية
Chicken Ovotransferrin Variants OTFB and OTFC Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity
| العنوان: | Chicken Ovotransferrin Variants OTFB and OTFC Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity |
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| المؤلفون: | Keiji Kinoshita, Si Lhyam Myint, Takeshi Shimogiri, Hisham R. Ibrahim, Kotaro Kawabe, Shin Okamoto, Yen-Pei Lee, Yoichi Matsuda, Yoshizane Maeda |
| المصدر: | The Journal of Poultry Science, Vol 53, Iss 4, Pp 257-263 (2016) |
| بيانات النشر: | Japan Poultry Science Association, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | antibacterial activity, chicken egg white, electrophoretic variant, ovotransferrin, snp, Animal culture, SF1-1100 |
| الوصف: | Chicken egg white ovotransferrin (OTF) has been reported to exist in three electrophoretic variants (OTFA, OTFB and OTFC). In this report, we identified a causal polymorphism between the OTFB and OTFC variants in Japanese and Taiwanese native chickens and compared the antibacterial activity between these two variants. The cDNA sequence analyses from Satsumadori oviducts revealed that three non-synonymous SNPs T1809G (Ser52Ala), A2258G (Ile96Val) and G7823A (Asp500Asn) corresponded to the OTF electrophoretic phenotypes. Of the three SNPs, the G7823A mutation perfectly corresponded to the electrophoretic phenotypes OTFB (G/G, Asp500Asp), OTFB/C (G/A, Asp500Asn) and OTFC (A/A, Asn500Asn) in three chicken populations. The variants OTFB and OTFC exhibited similar antibacterial potency against Gram-positive and Gram-negative bacteria. This study provides, for the first time, molecular information on polymorphism of OTFB and OTFC variants of chicken ovotransferrin and its effect on the antimicrobial activity of the respective variants. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1346-7395 1349-0486 |
| Relation: | https://www.jstage.jst.go.jp/article/jpsa/53/4/53_0160055/_pdf/-char/en; https://doaj.org/toc/1346-7395; https://doaj.org/toc/1349-0486 |
| DOI: | 10.2141/jpsa.0160055 |
| URL الوصول: | https://doaj.org/article/b3591dfa587c4f6c809f99a90d0a3926 |
| رقم الأكسشن: | edsdoj.b3591dfa587c4f6c809f99a90d0a3926 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 13467395 13490486 |
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| DOI: | 10.2141/jpsa.0160055 |