دورية أكاديمية
Treatment Outcomes of Patients with Multidrug-Resistant Tuberculosis: Comparison of Pre- and Post-Public–Private Mix Periods
| العنوان: | Treatment Outcomes of Patients with Multidrug-Resistant Tuberculosis: Comparison of Pre- and Post-Public–Private Mix Periods |
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| المؤلفون: | Yewon Kang, Eun-Jung Jo, Jung Seop Eom, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Jeongha Mok |
| المصدر: | Tuberculosis and Respiratory Diseases, Vol 84, Iss 1, Pp 74-83 (2021) |
| بيانات النشر: | The Korean Academy of Tuberculosis and Respiratory Diseases, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | multidrug-resistant tuberculosis, ppm, public–private mix, south korea, treatment outcome, Diseases of the respiratory system, RC705-779 |
| الوصف: | Background This study compared the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) before and after the implementation of public–private mix (PPM). Factors affecting treatment success were also investigated. Methods Data from culture-confirmed pulmonary MDR-TB patients who commenced MDR-TB treatment at Pusan National University Hospital between January 2003 and December 2017 were retrospectively reviewed. Patients were divided into two groups in terms of PPM status: pre-PPM period, patients who commenced MDR-TB treatment between 2003 and 2010; and post-PPM period, patients treated between 2011 and 2017. Results A total of 176 patients were included (64 and 112 in the pre- and post-PPM periods, respectively). 36.9% of the patients were resistant to a fluoroquinolone or a second-line injectable drug, or both. The overall treatment success rate was 72.7%. The success rate of post-PPM patients was higher than that of pre-PPM patients (79.5% vs. 60.9%, p=0.008). Also, loss to follow-up was lower in the post-PPM period (5.4% vs. 15.6%, p=0.023). In multivariate regression analysis, age ≥65 years, body mass index ≤18.5 kg/m2, previous TB treatment, bilateral lung involvement, and extensively drug-resistant (XDR)- or pre-XDR-TB were associated with poorer treatment outcomes. However, the use of bedaquiline or delamanid for ≥1 month increased the treatment success. Conclusion The treatment success rate in MDR-TB patients was higher in the post-PPM period than in the pre-PPM period, particularly because of the low rate of loss to follow-up. To ensure comprehensive patient-centered PPM in South Korea, investment and other support must be adequate. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1738-3536 2005-6184 |
| Relation: | http://www.e-trd.org/upload/pdf/trd-2020-0093.pdf; https://doaj.org/toc/1738-3536; https://doaj.org/toc/2005-6184 |
| DOI: | 10.4046/trd.2020.0093 |
| URL الوصول: | https://doaj.org/article/b3ba9d6ee987408ca238da9988c10cce |
| رقم الأكسشن: | edsdoj.b3ba9d6ee987408ca238da9988c10cce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17383536 20056184 |
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| DOI: | 10.4046/trd.2020.0093 |