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Early changes in soluble intracellular adhesion molecule‐1 as prognostic biomarkers to immune checkpoint inhibitor

التفاصيل البيبلوغرافية
العنوان: Early changes in soluble intracellular adhesion molecule‐1 as prognostic biomarkers to immune checkpoint inhibitor
المؤلفون: Dongmei Ji, Shiyu Jiang, Qunling Zhang, Y. Ken Wang, Jian Zhang, Weina Shen, Wenhua Li, Rujiao Liu, Jessica Wang, Cory Mavis, Juan J. Gu, Xichun Hu
المصدر: Clinical and Translational Science, Vol 16, Iss 8, Pp 1396-1407 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Therapeutics. Pharmacology
LCC:Public aspects of medicine
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270
الوصف: Abstract Serologic biomarker to predict clinical outcome is needed for immune checkpoint inhibitors (ICIs). We evaluated soluble intercellular adhesion molecules‐1 (sICAM‐1) as a predictor of response to ICIs treatment. Ninety‐five patients with cancer treated with ICI were studied. The serum sICAM‐1 levels of baseline, post two cycle therapy and end of therapy (EOT) were measured by enzyme‐linked immunoassay. We randomly assigned the patients into the primary cohort (n = 47) and validation cohort (n = 48). Serum sICAM‐1 post two cycle (277.7 ± 181.6 ng/mL) and EOT (403.9 ± 218.9 ng/mL) were significantly elevated compared to baseline (244.8 ± 153.8 ng/mL, p = 0.008 and p = 0.004, respectively). Early changes of sICAM‐1 (ΔsICAM‐1), deemed as sICAM‐1 after two cycles minus baseline, were assessed. Following ICI treatments, responders had significantly lower ΔsICAM‐1 compared with nonresponders in the primary cohort (p = 0.040) and the validation cohort (p = 0.026). High ΔsICAM‐1 was strongly associated with inferior progression‐free survival (PFS; (primary cohort: p = 0.001 and validation cohort: p = 0.002) and overall survival (OS; (primary cohort: p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1752-8062
1752-8054
Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062
DOI: 10.1111/cts.13540
URL الوصول: https://doaj.org/article/b3bf6dc625e243009db43c8ca3711a57
رقم الأكسشن: edsdoj.b3bf6dc625e243009db43c8ca3711a57
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17528062
17528054
DOI:10.1111/cts.13540