دورية أكاديمية
Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline
| العنوان: | Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline |
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| المؤلفون: | Vladimir Chobot, Franz Hadacek, Gert Bachmann, Wolfram Weckwerth, Lenka Kubicova |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 12, p 3917 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Alzheimer’s, Fenton reaction, hydroxyl radical, iron chelates, reactive oxygen species, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Background: The alkaloid 8-hydroxyquinoline (8HQ) is well-known for various biological activities, including antioxidant effects and especially for the formation of coordination complexes with various transition metals, such as iron, amongst others. Therefore, 8HQ was extensively explored as a promising antineurodegenerative agent. However, other authors noted pro-oxidant effects of 8HQ. Here, we explore the pro- and antioxidant properties of 8HQ, especially in context of coordination complexes with iron (II) and iron (III). Methods: Nano-electrospray−mass spectrometry, differential pulse voltammetry, deoxyribose degradation, iron (II) autoxidation, and brine shrimp mortality assays were used. Results: 8HQ formed a complex mixture of coordination complexes with iron (II) and iron (III). Furthermore, 8HQ showed antioxidant effects but no pro-oxidant ones. In the brine shrimp mortality assay, 8HQ demonstrated toxicity that decreased in the presence of iron (III). Conclusions: 8HQ is a potent antioxidant whose effects depend not only on the formation of the coordination complexes with iron ions, but surely on the scavenging activities due to the redox properties of the 8-hydroxyl group. No pro-oxidant effects were observed in the set of the used assays. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/19/12/3917; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms19123917 |
| URL الوصول: | https://doaj.org/article/b3df148798db4c74b45c2d4c4083e3bb |
| رقم الأكسشن: | edsdoj.b3df148798db4c74b45c2d4c4083e3bb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms19123917 |