دورية أكاديمية
The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis.
| العنوان: | The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis. |
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| المؤلفون: | Kai Heimel, Mario Scherer, Miroslav Vranes, Ramon Wahl, Chetsada Pothiratana, David Schuler, Volker Vincon, Florian Finkernagel, Ignacio Flor-Parra, Jörg Kämper |
| المصدر: | PLoS Pathogens, Vol 6, Iss 8, p e1001035 (2010) |
| بيانات النشر: | Public Library of Science (PLoS), 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| الوصف: | In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7366 1553-7374 |
| Relation: | http://europepmc.org/articles/PMC2916880?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: | 10.1371/journal.ppat.1001035 |
| URL الوصول: | https://doaj.org/article/ab4064c79da44eed9eed95563fe08991 |
| رقم الأكسشن: | edsdoj.b4064c79da44eed9eed95563fe08991 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1001035 |