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Brain Organoids to Evaluate Cellular Therapies

التفاصيل البيبلوغرافية
العنوان: Brain Organoids to Evaluate Cellular Therapies
المؤلفون: Ana Belén García-Delgado, Rafael Campos-Cuerva, Cristina Rosell-Valle, María Martin-López, Carlos Casado, Daniela Ferrari, Javier Márquez-Rivas, Rosario Sánchez-Pernaute, Beatriz Fernández-Muñoz
المصدر: Animals, Vol 12, Iss 22, p 3150 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Veterinary medicine
LCC:Zoology
مصطلحات موضوعية: brain organoids, cell therapy, neural stem cells, neural progenitors, translation, 3 Rs, Veterinary medicine, SF600-1100, Zoology, QL1-991
الوصف: Animal models currently used to test the efficacy and safety of cell therapies, mainly murine models, have limitations as molecular, cellular, and physiological mechanisms are often inherently different between species, especially in the brain. Therefore, for clinical translation of cell-based medicinal products, the development of alternative models based on human neural cells may be crucial. We have developed an in vitro model of transplantation into human brain organoids to study the potential of neural stem cells as cell therapeutics and compared these data with standard xenograft studies in the brain of immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice. Neural stem cells showed similar differentiation and proliferation potentials in both human brain organoids and mouse brains. Our results suggest that brain organoids can be informative in the evaluation of cell therapies, helping to reduce the number of animals used for regulatory studies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-2615
Relation: https://www.mdpi.com/2076-2615/12/22/3150; https://doaj.org/toc/2076-2615
DOI: 10.3390/ani12223150
URL الوصول: https://doaj.org/article/eb409fb6863f4ac19c79b4c348cdf70d
رقم الأكسشن: edsdoj.b409fb6863f4ac19c79b4c348cdf70d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20762615
DOI:10.3390/ani12223150