دورية أكاديمية
Chronic Administration of Exogenous Lactate Increases Energy Expenditure during Exercise through Activation of Skeletal Muscle Energy Utilization Capacity in Mice
| العنوان: | Chronic Administration of Exogenous Lactate Increases Energy Expenditure during Exercise through Activation of Skeletal Muscle Energy Utilization Capacity in Mice |
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| المؤلفون: | Inkwon Jang, Sunghwan Kyun, Deunsol Hwang, Taeho Kim, Kiwon Lim, Hun-Young Park, Sung-Woo Kim, Jisu Kim |
| المصدر: | Metabolites, Vol 14, Iss 4, p 220 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | chronic exogenous lactate, exercise training, metabolic during exercise, energy substrate utilization, body composition, metabolic regulator, Microbiology, QR1-502 |
| الوصف: | We compared the effects of chronic exogenous lactate and exercise training, which influence energy substrate utilization and body composition improvements at rest and during exercise, and investigated the availability of lactate as a metabolic regulator. The mice were divided into four groups: CON (sedentary + saline), LAC (sedentary + lactate), EXE (exercise + saline), and EXLA (exercise + lactate). The total experimental period was set at 4 weeks, the training intensity was set at 60–70% VO2max, and each exercise group was administered a solution immediately after exercise. Changes in the energy substrate utilization at rest and during exercise, the protein levels related to energy substrate utilization in skeletal muscles, and the body composition were measured. Lactate intake and exercise increased carbohydrate oxidation as a substrate during exercise, leading to an increased energy expenditure and increased protein levels of citrate synthase and malate dehydrogenase 2, key factors in the TCA(tricarboxylic acid) cycle of skeletal muscle. Exercise, but not lactate intake, induced the upregulation of the skeletal muscle glucose transport factor 4 and a reduction in body fat. Hence, chronic lactate administration, as a metabolic regulator, influenced energy substrate utilization by the skeletal muscle and increased energy expenditure during exercise through the activation of carbohydrate metabolism-related factors. Therefore, exogenous lactate holds potential as a metabolic regulator. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14040220 2218-1989 |
| Relation: | https://www.mdpi.com/2218-1989/14/4/220; https://doaj.org/toc/2218-1989 |
| DOI: | 10.3390/metabo14040220 |
| URL الوصول: | https://doaj.org/article/b41ab80d4bde4611ba5f97dcc971787f |
| رقم الأكسشن: | edsdoj.b41ab80d4bde4611ba5f97dcc971787f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14040220 22181989 |
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| DOI: | 10.3390/metabo14040220 |