دورية أكاديمية
The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease
| العنوان: | The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease |
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| المؤلفون: | Steven Nicolaides, Abhinav Vasudevan, Tony Long, Daniel van Langenberg |
| المصدر: | Intestinal Research, Vol 19, Iss 2, Pp 158-170 (2021) |
| بيانات النشر: | Korean Association for the Study of Intestinal Diseases, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | smoking, tobacco, inflammatory bowel disease, crohn disease, therapeutics, Medicine, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Smoking significantly increases the risk of developing and worsens Crohn’s disease (CD), yet protects against the development and reduces the severity of ulcerative colitis. It is less clear whether smoking impacts the efficacy of therapeutics in inflammatory bowel disease (IBD). We review the literature regarding the relationship between smoking and the efficacy of medical and surgical therapy in IBD. Smoking is associated with alterations in thiopurine metabolism and may affect time to disease relapse. The outcomes of anti-tumor necrosis factor therapy in active smokers appear neutral with data lacking for newer biologics. Smoking increases the risk of postoperative recurrence in those requiring resection for CD, likely attributable to perturbations of the gut microbiota although further implications of these for disease onset/progression and treatment efficacy remain unclear. Multiple lifestyle and psychosocial confounders are likely under-recognized cofactors in the association between smoking and IBD. Despite the widely promulgated risks associated with cigarette smoking in CD, more incisive data are required to further elucidate the actual relationship between smoking and disease pathways, while accounting for the several negative cofactors prevalent in smokers which cast uncertainty on the magnitude of the direct effect of smoking on disease pathophysiology and the efficacy of therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1598-9100 2288-1956 |
| Relation: | http://www.irjournal.org/upload/pdf/ir-2020-00008.pdf; https://doaj.org/toc/1598-9100; https://doaj.org/toc/2288-1956 |
| DOI: | 10.5217/ir.2020.00008 |
| URL الوصول: | https://doaj.org/article/b46fac0986814aa59911d0ada15fbbae |
| رقم الأكسشن: | edsdoj.b46fac0986814aa59911d0ada15fbbae |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15989100 22881956 |
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| DOI: | 10.5217/ir.2020.00008 |