دورية أكاديمية
Role of STREM-1 for early prediction of ventilator-associated pneumonia in pediatrics
| العنوان: | Role of STREM-1 for early prediction of ventilator-associated pneumonia in pediatrics |
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| المؤلفون: | Tarek Ahmed Abdelgawad, Maha Ahmad Anwar, Sondos Mohamed Magdy, Mohamed El-Sayed Abd El-Maksoud Abd El-Maksoud |
| المصدر: | The Egyptian Journal of Bronchology, Vol 18, Iss 1, Pp 1-7 (2024) |
| بيانات النشر: | SpringerOpen, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the respiratory system LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: | Pneumonia, Pediatrics, STREM-1, Mechanical ventilation, Diseases of the respiratory system, RC705-779, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: | Abstract Background TREM-1 (setting off receptor imparted on myeloid cells-1) is an immunoreceptor. Neutrophils, monocytes/macrophages, and endothelial cells all express TREM-1. This work aimed to evaluate the role of STREM-1 in ventilator-associated pneumonia (VAP) early prediction in pediatrics. Methods This case–control research involved 56 children aged from 1 month to 5 years old, who were admitted to the pediatric intensive care unit (PICU) and needed mechanical ventilation (MV), from January 2023 to June 2023. Subjects were equally allocated into two groups: VAP group and non-VAP group. Results There was significantly elevated serum STREM-1 after 72 h than at admission between both groups. There was significantly elevated STREM-1, procalcitonin (PCT), and C-reactive protein (CRP) after 72 h in the VAP group compared to the non-VAP group. There was a positive correlation between PCT and CRP after 72 h. STREM-1 at admission and after 72 h area under the curve (AUC) was 0.641 (0.502 to 0.765), 1.000 (0.936 to 1.000), with best cut-off value for prediction of VAP was > 185, > 230 with sensitivity 53.6%, 100% and specificity 67.9%, 100%, respectively. Conclusion Serum sTREM-1 concentration is a reliable biomarker for predicting VAP in pediatrics received MV. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-8551 |
| Relation: | https://doaj.org/toc/2314-8551 |
| DOI: | 10.1186/s43168-024-00268-z |
| URL الوصول: | https://doaj.org/article/b471d78945a04ecd9e5c2cfc6da597db |
| رقم الأكسشن: | edsdoj.b471d78945a04ecd9e5c2cfc6da597db |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23148551 |
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| DOI: | 10.1186/s43168-024-00268-z |