دورية أكاديمية
Structural modifications and augmented affinity for bile salts in enzymatically denatured egg white
| العنوان: | Structural modifications and augmented affinity for bile salts in enzymatically denatured egg white |
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| المؤلفون: | Chunjie Liu, Yating Wu, Guoguo Jin, Baocai Xu, Lin Mei |
| المصدر: | Food Chemistry: X, Vol 23, Iss , Pp 101577- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture |
| مصطلحات موضوعية: | Egg white protein, Bile salts binding ability, In vitro simulation of gastrointestinal digestion, Structure-activity relationship, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456 |
| الوصف: | Protein binding to bile salts (BSs) reduces cholesterol levels, but the exact mechanism is unclear. In this study, we performed simulated gastrointestinal digestion of egg white protein hydrolysate (EWPHs) and included an unenzyme digestion group (CK) to investigate the changes in BSs binding capacity before and after digestion, as well as the relationship between egg white protein (EWP) structure and BSs binding capacity. In addition, peptidomics and molecular docking were used to clarify EWP's binding mechanism. We found that the BSs binding ability of EWPHs was slightly decreased after digestion, but significantly higher than that of the CK group and the digested CK group (D-CK). Particle size analysis and electrophoresis demonstrated that smaller particles and lower molecular weights exhibited enhanced binding capacity to BSs. Fourier Transform infrared spectroscopy (FTIR) results revealed that a disordered structure favored BS binding ability enhancement. Peptides FVLPM and GGGVW displayed hypocholesterolemic efficacy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-1575 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590157524004656; https://doaj.org/toc/2590-1575 |
| DOI: | 10.1016/j.fochx.2024.101577 |
| URL الوصول: | https://doaj.org/article/b4853d13d9344169bf755349bafc6a4b |
| رقم الأكسشن: | edsdoj.b4853d13d9344169bf755349bafc6a4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25901575 |
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| DOI: | 10.1016/j.fochx.2024.101577 |