دورية أكاديمية
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study
| العنوان: | Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study |
|---|---|
| المؤلفون: | Hadba Al-Amrah, Omar I Saadah, Mahmoud Mosli, Vito Annese, Rashad Al-Hindi, Sherif Edris, Dikhnah Alshehri, Hanan Alatawi, Marfat Alatawy, Ahmad Bahieldin |
| المصدر: | The Saudi Journal of Gastroenterology, Vol 29, Iss 2, Pp 102-110 (2023) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | inflammatory bowel disease, microbiota, saudi arabia, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Conclusions: The results of this study provide an overview of the variations in microbiota diversity present in Saudi IBD patients compared to healthy controls. Results: The key finding was three negative bacterial biomarkers, Paraprevotellaceae, the Muribaculaceae families of Bacteroidetes phylum, and the Leuconostocaceae family of Firmicutes phylum, which had a higher relative abundance in healthy individuals compared to IBD patients. It was also found that primary microbiota signatures at certain genera and species levels, including Prevotella copri, Bifidobacterium adolescentis, Ruminococcus callidus, Coprococcus sp., Ruminococcus gnavus, Dorea formicigenerans, Leuconostoc, Dialister, Catenibacterium, Eubacterium biforme, and Lactobacillus mucosae, were absent in almost all IBD patients, while Veillonella dispar was absent in all healthy individuals. Methods: After obtaining an informed consent, fecal samples were collected from 11 participants with IBD (patients) and 10 healthy individuals (controls). The bacterial components of the microbial population were identified by next-generation sequencing of partial 16S rRNA. Statistically significant dissimilarities were observed between samples for all metrics. Background: Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition attributed to a complex interaction between imbalances in the gut microbiome, environmental conditions, and a deregulated immune response. The aim of the study was to investigate the composition of the gut microbiome of Saudi patients with IBD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1319-3767 1998-4049 |
| Relation: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=2;spage=102;epage=110;aulast=Al-Amrah; https://doaj.org/toc/1319-3767; https://doaj.org/toc/1998-4049 |
| DOI: | 10.4103/sjg.sjg_368_22 |
| URL الوصول: | https://doaj.org/article/b510da5557c6435785876ac91fa210de |
| رقم الأكسشن: | edsdoj.b510da5557c6435785876ac91fa210de |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13193767 19984049 |
|---|---|
| DOI: | 10.4103/sjg.sjg_368_22 |