دورية أكاديمية
Proteomics study of Mongolian medicine warm acupuncture in the treatment of p-chlorophenylalanine-induced insomnia in rats
| العنوان: | Proteomics study of Mongolian medicine warm acupuncture in the treatment of p-chlorophenylalanine-induced insomnia in rats |
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| المؤلفون: | Yanan Xu, Jianxun Wen, Wenyan Han, Gula A, Xiulan Su |
| المصدر: | All Life, Vol 17, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Life |
| مصطلحات موضوعية: | mongolian medicine warm acupuncture, insomnia, itraq, hippocampus, Biotechnology, TP248.13-248.65, Life, QH501-531 |
| الوصف: | Mongolian medical warm acupuncture (MMWA) therapy is a traditional external therapy method that has a definite clinical effect in the treatment of insomnia, but research on its underlying neural mechanisms remains limited. iTRAQ-based quantitative proteomics was used to identify proteins that are potential neural molecules involved in the treatment of insomnia by MMWA. In this study, 6383 proteins were identified, including 45 proteins with increased expression and 31 proteins with decreased expression in the insomnia model group (M) compared to the control group (C); 101 proteins showed an increase and 48 proteins showed a decrease between the warm acupuncture group (W) and C; 26 proteins showed an increase and 22 proteins showed a decrease between W and M. GO and KEGG analysis showed that MMWA treatment of insomnia was closely related to metabolism and hormone synthesis. Differentially expressed proteins included albumin (ALB), Pro-MCH (PMCH), acetoacetyl-CoA synthetase (AACS), N-ethylmaleimide sensitive factor (NSF), potassium/sodium hyperpolarization-activated cyclic-nucleotide gated channel 4 (HCN4) and Ciapin1, which are important proteins for MMWA treatment of insomnia. The iTRAQ-based proteomics data analyses presented here elucidate variations in the expression of proteins involved in the treatment of insomnia by MMWA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2689-5307 26895293 |
| Relation: | https://doaj.org/toc/2689-5307 |
| DOI: | 10.1080/26895293.2024.2316088 |
| URL الوصول: | https://doaj.org/article/b520f0f6b7ee47589a03f6f293fb4b8f |
| رقم الأكسشن: | edsdoj.b520f0f6b7ee47589a03f6f293fb4b8f |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 26895307 26895293 |
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| DOI: | 10.1080/26895293.2024.2316088 |