دورية أكاديمية
The Transmission of Intergenerational Epigenetic Information by Sperm microRNAs
| العنوان: | The Transmission of Intergenerational Epigenetic Information by Sperm microRNAs |
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| المؤلفون: | Grace S. Lee, Colin C. Conine |
| المصدر: | Epigenomes, Vol 6, Iss 2, p 12 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Genetics LCC:Biotechnology |
| مصطلحات موضوعية: | microRNAs, sperm, epigenetic inheritance, environmental exposures, Genetics, QH426-470, Biotechnology, TP248.13-248.65 |
| الوصف: | Epigenetic information is transmitted from one generation to the next, modulating the phenotype of offspring non-genetically in organisms ranging from plants to mammals. For intergenerational non-genetic inheritance to occur, epigenetic information must accumulate in germ cells. The three main carriers of epigenetic information—histone post-translational modifications, DNA modifications, and RNAs—all exhibit dynamic patterns of regulation during germ cell development. For example, histone modifications and DNA methylation are extensively reprogrammed and often eliminated during germ cell maturation and after fertilization during embryogenesis. Consequently, much attention has been given to RNAs, specifically small regulatory RNAs, as carriers of inherited epigenetic information. In this review, we discuss examples in which microRNAs have been implicated as key players in transmitting paternal epigenetic information intergenerationally. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2075-4655 |
| Relation: | https://www.mdpi.com/2075-4655/6/2/12; https://doaj.org/toc/2075-4655 |
| DOI: | 10.3390/epigenomes6020012 |
| URL الوصول: | https://doaj.org/article/b5482f5cba364bdfaaa917625607f5d3 |
| رقم الأكسشن: | edsdoj.b5482f5cba364bdfaaa917625607f5d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20754655 |
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| DOI: | 10.3390/epigenomes6020012 |