دورية أكاديمية
Gas6/TAM Axis Involvement in Modulating Inflammation and Fibrosis in COVID-19 Patients
| العنوان: | Gas6/TAM Axis Involvement in Modulating Inflammation and Fibrosis in COVID-19 Patients |
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| المؤلفون: | Manuela Rizzi, Stelvio Tonello, Davide D’Onghia, Pier Paolo Sainaghi |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 2, p 951 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Gas6, TAM receptors, inflammation, fibrosis, COVID-19, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Gas6 (growth arrest-specific gene 6) is a widely expressed vitamin K-dependent protein that is involved in many biological processes such as homeostatic regulation, inflammation and repair/fibrotic processes. It is known that it is the main ligand of TAMs, a tyrosine kinase receptor family of three members, namely MerTK, Tyro-3 and Axl, for which it displays the highest affinity. Gas6/TAM axis activation is known to be involved in modulating inflammatory responses as well as fibrotic evolution in many different pathological conditions. Due to the rapidly evolving COVID-19 pandemic, this review will focus on Gas6/TAM axis activation in SARS-CoV-2 infection, where de-regulated inflammatory responses and fibrosis represent a relevant feature of severe disease manifestation. Furthermore, this review will highlight the most recent scientific evidence supporting an unsuspected role of Axl as a SARS-CoV-2 infection driver, and the potential therapeutic advantages of the use of existing Axl inhibitors in COVID-19 management. From a physiological point of view, the Gas6/TAM axis plays a dual role, fostering the tissue repair processes or leading to organ damage and loss of function, depending on the prevalence of its anti-inflammatory or profibrotic properties. This review makes a strong case for further research focusing on the Gas6/TAM axis as a pharmacological target to manage different disease conditions, such as chronic fibrosis or COVID-19. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/2/951; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24020951 |
| URL الوصول: | https://doaj.org/article/b54d8b5c8bf94ca585f53d579200b5bf |
| رقم الأكسشن: | edsdoj.b54d8b5c8bf94ca585f53d579200b5bf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms24020951 |