دورية أكاديمية
Prodigiosin as an Antibiofilm Agent against the Bacterial Biofilm-Associated Infection of Pseudomonas aeruginosa
| العنوان: | Prodigiosin as an Antibiofilm Agent against the Bacterial Biofilm-Associated Infection of Pseudomonas aeruginosa |
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| المؤلفون: | Zhiwen Ma, Hong Xiao, Hailin Li, Xiaoling Lu, Jing Yan, Hao Nie, Qi Yin |
| المصدر: | Pathogens, Vol 13, Iss 2, p 145 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Pseudomonas aeruginosa, prodigiosin, anti-biofilm, chronic lung infection, Medicine |
| الوصف: | Pseudomonas aeruginosa is known to generate bacterial biofilms that increase antibiotic resistance. With the increase of multi-drug resistance in recent years, the formulation of a new therapeutic strategy has seemed urgent. Preliminary findings show that Prodigiosin (PG), derived from chromium-resistant Serratia marcescens, exhibited efficient anti-biofilm activity against Staphylococcus aureus. However, its anti-biofilm activity against P. aeruginosa remains largely unexplored. The anti-biofilm activity of PG against three clinical single drug-resistant P. aeruginosa was evaluated using crystal violet staining, and the viability of biofilms and planktonic cells were also assessed. A model of chronic lung infection was constructed to test the in vivo antibiofilm activity of PG. The results showed that PG inhibited biofilm formation and effectively inhibited the production of pyocyanin and extracellular polysaccharides in vitro, as well as moderated the expression of interleukins (IL-1β, IL-6, IL-10) and tumor necrosis factor (TNF-α) in vivo, which might be attributed to the downregulation of biofilm-related genes such as algA, pelA, and pslM. These findings suggest that PG could be a potential treatment for drug-resistant P aeruginosa and chronic biofilm infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13020145 2076-0817 |
| Relation: | https://www.mdpi.com/2076-0817/13/2/145; https://doaj.org/toc/2076-0817 |
| DOI: | 10.3390/pathogens13020145 |
| URL الوصول: | https://doaj.org/article/b555542ff49b426a95345be970108e6e |
| رقم الأكسشن: | edsdoj.b555542ff49b426a95345be970108e6e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13020145 20760817 |
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| DOI: | 10.3390/pathogens13020145 |