دورية أكاديمية
Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery
| العنوان: | Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery |
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| المؤلفون: | Yinxiang Tang, Minhui Hu, Fuxin Tang, Rongkang Huang, Hui Wang, Dingcai Wu, Ping Lan |
| المصدر: | Bioactive Materials, Vol 15, Iss , Pp 44-52 (2022) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| مصطلحات موضوعية: | Shear-thinning, Injectable hydrogel, Gellan gum, Long-lasting barrier, Endoscopic surgery, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| الوصف: | Submucosal injection material has shown protective effect against gastrointestinal injury during endoscopic surgery in clinic. However, the protective ability of existing submucosal injection material is strictly limited by their difficult injectability and short barrier time. Herein, we report a shear-thinning gellan gum hydrogel that simultaneously has easy injectability and long-lasting barrier function, together with good hemostatic property and biocompatibility. Shear-thinning property endows our gellan gum hydrogel with excellent endoscopic injection performance, and the injection pressure of our gellan gum hydrogel is much lower than that of the small molecule solution (50 wt% dextrose) when injected through the endoscopic needle. More importantly, our gellan gum hydrogel shows much stronger barrier retention ability than normal saline and sodium hyaluronate solution in the ex vivo and in vivo models. Furthermore, our epinephrine-containing gellan gum hydrogel has a satisfactory hemostatic effect in the mucosal lesion resection model of pig. These results indicate an appealing application prospect for gellan gum hydrogel utilizing as a submucosal injection material in endoscopic surgery. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X21005570; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2021.11.026 |
| URL الوصول: | https://doaj.org/article/b562dc296b744166a77ac1c7a46af318 |
| رقم الأكسشن: | edsdoj.b562dc296b744166a77ac1c7a46af318 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2021.11.026 |