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Pathological resting-state executive and language system perfusion in first-episode psychosis

التفاصيل البيبلوغرافية
العنوان: Pathological resting-state executive and language system perfusion in first-episode psychosis
المؤلفون: Dean F. Salisbury, Mark Curtis, Julia Longenecker, Fang-Cheng Yeh, Tae Kim, Brian A. Coffman
المصدر: NeuroImage: Clinical, Vol 36, Iss , Pp 103261- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: First episode psychosis, Basal perfusion, Arterial spin labeling, Auditory hallucinations, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: Background and hypothesis: Cortical (e.g., Broca’s area and Wernicke’s area) and subcortical (e.g., putamen) language-related areas and executive control areas (e.g., inferior frontal gyrus (IFG), dorsolateral prefrontal cortex (DLPFC)) show functional and structural dysconnectivity in long-term psychosis. We examined whether resting-state basal perfusion levels revealed selective pathophysiology (likely hypo- and hyper-activation) of language-related and executive areas in first-episode psychosis (FEP). Study design: Basal resting-state perfusion was measured using pseudo-continuous Arterial Spin Labeling (pcASL). Relative cerebral blood flow (rCBF) was compared between 32 FEP and 34 matched healthy comparison (HC) individuals. Structural and functional MRI scans were acquired using a 3T Prisma scanner during the same session. Study results: Whole-brain comparison of resting rCBF identified 8 clusters with significant between-group differences. Reduced rCBF was found in executive control areas in left and right IFG, right DLPFC, and right parietal cortex. Increased rCBF was found in left and right temporal cortex (including Wernicke’s area), and left and right putamen. A positive correlation was observed between auditory hallucination severity and rCBF in the left putamen. Conclusions: To the degree that perfusion implies activation, language and auditory processing areas in bilateral temporal lobe and putamen showed pathological hyper-activity, and cognitive control areas (IFG, DLPFC, right parietal) showed pathological hypo-activity in FEP at rest. Pathological basal activity was present across the range of symptom severity, suggesting it may be a common underlying pathology for psychosis that may be targeted with non-invasive brain stimulation to normalize resting activity levels.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-1582
Relation: http://www.sciencedirect.com/science/article/pii/S2213158222003266; https://doaj.org/toc/2213-1582
DOI: 10.1016/j.nicl.2022.103261
URL الوصول: https://doaj.org/article/b574013593354dcd8f8f038e7e2539b4
رقم الأكسشن: edsdoj.b574013593354dcd8f8f038e7e2539b4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22131582
DOI:10.1016/j.nicl.2022.103261