دورية أكاديمية
Protein corona – from molecular adsorption to physiological complexity
| العنوان: | Protein corona – from molecular adsorption to physiological complexity |
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| المؤلفون: | Lennart Treuel, Dominic Docter, Michael Maskos, Roland H. Stauber |
| المصدر: | Beilstein Journal of Nanotechnology, Vol 6, Iss 1, Pp 857-873 (2015) |
| بيانات النشر: | Beilstein-Institut, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Technology LCC:Chemical technology LCC:Science LCC:Physics |
| مصطلحات موضوعية: | agglomeration, corona composition, dynamics, nanoparticles, protein corona, Technology, Chemical technology, TP1-1185, Science, Physics, QC1-999 |
| الوصف: | In biological environments, nanoparticles are enshrouded by a layer of biomolecules, predominantly proteins, mediating its subsequent interactions with cells. Detecting this protein corona, understanding its formation with regards to nanoparticle (NP) and protein properties, and elucidating its biological implications were central aims of bio-related nano-research throughout the past years. Here, we discuss the mechanistic parameters that are involved in the protein corona formation and the consequences of this corona formation for both, the particle, and the protein. We review consequences of corona formation for colloidal stability and discuss the role of functional groups and NP surface functionalities in shaping NP–protein interactions. We also elaborate the recent advances demonstrating the strong involvement of Coulomb-type interactions between NPs and charged patches on the protein surface. Moreover, we discuss novel aspects related to the complexity of the protein corona forming under physiological conditions in full serum. Specifically, we address the relation between particle size and corona composition and the latest findings that help to shed light on temporal evolution of the full serum corona for the first time. Finally, we discuss the most recent advances regarding the molecular-scale mechanistic role of the protein corona in cellular uptake of NPs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2190-4286 |
| Relation: | https://doaj.org/toc/2190-4286 |
| DOI: | 10.3762/bjnano.6.88 |
| URL الوصول: | https://doaj.org/article/b58acd3d921e442dad30686ddf874609 |
| رقم الأكسشن: | edsdoj.b58acd3d921e442dad30686ddf874609 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21904286 |
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| DOI: | 10.3762/bjnano.6.88 |