دورية أكاديمية
(Z)-Selective Takai olefination of salicylaldehydes
| العنوان: | (Z)-Selective Takai olefination of salicylaldehydes |
|---|---|
| المؤلفون: | Stephen M. Geddis, Caroline E. Hagerman, Warren R. J. D. Galloway, Hannah F. Sore, Jonathan M. Goodman, David R. Spring |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 323-328 (2017) |
| بيانات النشر: | Beilstein-Institut, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | alkenyl iodides, salicylaldehydes, stereoselectivity, Takai olefination, transition state, Science, Organic chemistry, QD241-441 |
| الوصف: | The Takai olefination (or Takai reaction) is a method for the conversion of aldehydes to vinyl iodides, and has seen widespread implementation in organic synthesis. The reaction is usually noted for its high (E)-selectivity; however, herein we report the highly (Z)-selective Takai olefination of salicylaldehyde derivatives. Systematic screening of related substrates led to the identification of key factors responsible for this surprising inversion of selectivity, and enabled the development of a modified mechanistic model to rationalise these observations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| Relation: | https://doaj.org/toc/1860-5397 |
| DOI: | 10.3762/bjoc.13.35 |
| URL الوصول: | https://doaj.org/article/db590cb3d79c4c7c91990818a9ee7a4f |
| رقم الأكسشن: | edsdoj.b590cb3d79c4c7c91990818a9ee7a4f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
|---|---|
| DOI: | 10.3762/bjoc.13.35 |