دورية أكاديمية
Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
| العنوان: | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
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| المؤلفون: | Sergio Bagnato, Maria Enza D’Ippolito, Cristina Boccagni, Antonio De Tanti, Lucia Francesca Lucca, Antonio Nardone, Pamela Salucci, Teresa Fiorilla, Valeria Pingue, Serena Gennaro, Maria Ursino, Valentina Colombo, Teresa Barone, Francesca Rubino, Maria Andriolo |
| المصدر: | Brain Sciences, Vol 11, Iss 8, p 1068 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | neurofilament light chain, traumatic brain injury, hypoxic-ischemic brain injury, unresponsive wakefulness syndrome, vegetative state, minimally conscious state, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | (1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscious state (MCS) after traumatic brain injury (TBI) and hypoxic-ischemic brain injury (HIBI). (2) Methods: This prospective multicenter blinded study involved 70 patients with prolonged DOC and 70 sex-/age-matched healthy controls. Serum NFL levels were evaluated at 1–3 and 6 months post-injury and compared with those of controls. NFL levels were compared by DOC severity (UWS vs. MCS) and etiology (TBI vs. HIBI). (3) Results: Patients’ serum NFL levels were significantly higher than those of controls at 1–3 and 6 months post-injury (medians, 1729 and 426 vs. 90 pg/mL; both p < 0.0001). NFL levels were higher in patients with UWS than in those in MCS at 1–3 months post-injury (p = 0.008) and in patients with HIBI than in those with TBI at 6 months post-injury (p = 0.037). (4) Conclusions: Patients with prolonged DOC present sustained axonal degeneration that is affected differently over time by brain injury severity and etiology. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-3425 84815906 |
| Relation: | https://www.mdpi.com/2076-3425/11/8/1068; https://doaj.org/toc/2076-3425 |
| DOI: | 10.3390/brainsci11081068 |
| URL الوصول: | https://doaj.org/article/b5a26133aaa848159063b272b8c66bad |
| رقم الأكسشن: | edsdoj.b5a26133aaa848159063b272b8c66bad |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20763425 84815906 |
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| DOI: | 10.3390/brainsci11081068 |