دورية أكاديمية
Posaconazole as rescue therapy in African histoplasmosis
| العنوان: | Posaconazole as rescue therapy in African histoplasmosis |
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| المؤلفون: | Daniel Gonçalves, Catarina Ferraz, Luisa Vaz |
| المصدر: | Brazilian Journal of Infectious Diseases, Vol 17, Iss 1, Pp 102-105 |
| بيانات النشر: | Elsevier. |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | Posaconazole, Histoplasmosis, Salvage therapy, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | Posaconazole Histoplasmosis Salvage therapy African histoplasmosis is a granulomatous mycosis caused by Histoplasma capsulatum var. duboisii. Treatment is usually extrapolated from guidelines for classical histoplasmosis, and includes 2-4 weeks of amphotericin B followed by a step-down maintenance therapy with itraconazole. Pediatric usage of posaconazole, an oral second-generation azole, remains off-label, but recent surveys show that it is safe and well tolerated in children. We report a case of disseminated African histoplasmosis in a 12-year-old boy from Guinea-Bissau. Therapy with amphotericin B and itraconazole led to a progressive clinical deterioration. A dramatic and lasting improvement was observed using posaconazole. He completed 12 months of therapy. No relapse was noted during or 3 months after treatment. We report that posaconazole may be a safe and efficacious drug in the salvage management of disseminated AH, either in patients with disease refractory to conventional anti-fungal therapy, or in patients whose serious adverse effects of first-line drugs preclude its use. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-4391 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100018&lng=en&tlng=en; https://doaj.org/toc/1678-4391 |
| DOI: | 10.1016/j.bjid.2012.06.027 |
| URL الوصول: | https://doaj.org/article/b5a3db2bffe944da8a19080a7cba25a3 |
| رقم الأكسشن: | edsdoj.b5a3db2bffe944da8a19080a7cba25a3 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16784391 |
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| DOI: | 10.1016/j.bjid.2012.06.027 |