دورية أكاديمية
Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent.
| العنوان: | Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent. |
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| المؤلفون: | Leonie J M Mekenkamp, Josien C Haan, Daniëlle Israeli, Hendrik F B van Essen, Jeroen R Dijkstra, Patricia van Cleef, Cornelis J A Punt, Gerrit A Meijer, Iris D Nagtegaal, Bauke Ylstra |
| المصدر: | PLoS ONE, Vol 9, Iss 2, p e86833 (2014) |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3914793?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0086833 |
| URL الوصول: | https://doaj.org/article/b619380266b84ea4a698141d31720e45 |
| رقم الأكسشن: | edsdoj.b619380266b84ea4a698141d31720e45 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0086833 |