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أعرض في EDS

Immunoexpression of estrogen receptor-β and progesterone receptor in prostate adenocarcinoma, does it inhibit neoplastic proliferation and invasion?

التفاصيل البيبلوغرافية
العنوان: Immunoexpression of estrogen receptor-β and progesterone receptor in prostate adenocarcinoma, does it inhibit neoplastic proliferation and invasion?
المؤلفون: Kinjal N Bera, Shakti K Yadav, Om Prakash, Sompal Singh, Namrata Sarin
المصدر: Indian Journal of Pathology and Microbiology, Vol 63, Iss 5, Pp 30-33 (2020)
بيانات النشر: Wolters Kluwer Medknow Publications, 2020.
سنة النشر: 2020
المجموعة: LCC:Pathology
LCC:Microbiology
مصطلحات موضوعية: estrogen receptor-beta, ki-67, progesterone receptor, prostate carcinoma, Pathology, RB1-214, Microbiology, QR1-502
الوصف: Context: The roles of estrogen and progesterone in human prostate carcinogenesis have been only recently recognized. Aims: This study was conducted to evaluate the expressions of esterone receptor-beta (ER-β), progesterone receptor (PR), and Ki-67 in benign and malignant lesions of the prostate. Settings and Design: The study was conducted at a tertiary care hospital. It was an analytical cross-sectional study. Materials and Methods: We selected a total of 39 cases including 26 cases of benign prostatic hyperplasia and 13 cases of adenocarcinoma prostate. The proportion of cases showing expression for ER-β, PR, and Ki-67 was noted for both groups. A difference in immunoexpression between benign and malignant cases was evaluated. Association between receptor expression and Gleason grade was evaluated for malignant cases. Statistical Analysis Used: To compare the difference in expressions of ER-β, PR, and Ki-67 Mann–Whitney U test was used. Association between ER-β, PR, and Ki-67 expression and Gleason grade was analyzed using the Chi-square test. Results: ER-β expression was seen in all benign and malignant cases, whereas the majority of the malignant cases (61.54%) were negative for progesterone expression. Epithelial expressions of ER-β and PR were significantly higher in benign as compared with malignant lesions. Malignant cases showed a significantly higher expression of Ki-67. However, we did not find any association between the expressions of these markers with Gleason grade. Conclusions: The expressions of ER-β and PR were significantly higher in the epithelium in benign cases as compared with malignant cases. Ki-67 expression was significantly higher in the malignant group as compared with the benign group.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0377-4929
Relation: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=5;spage=30;epage=33;aulast=Bera; https://doaj.org/toc/0377-4929
DOI: 10.4103/IJPM.IJPM_467_18
URL الوصول: https://doaj.org/article/b62186820d0541ada7844d733b9eb43c
رقم الأكسشن: edsdoj.b62186820d0541ada7844d733b9eb43c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03774929
DOI:10.4103/IJPM.IJPM_467_18