دورية أكاديمية

Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits

التفاصيل البيبلوغرافية
العنوان: Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits
المؤلفون: Elaine Tierney, Alan T. Remaley, Audrey Thurm, Leah R. Jager, Christopher A. Wassif, Lisa E. Kratz, Joan E. Bailey-Wilson, Irena Bukelis, Geeta Sarphare, Eun Sol Jung, Boudewien Brand, Kelly K. Noah, Forbes D. Porter
المصدر: Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
بيانات النشر: Nature Publishing Group, 2021.
سنة النشر: 2021
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with ≥2 children with ASD participating with the Autism Genetic Resource Exchange (AGRE), as well as reduced amounts of high-density lipoprotein cholesterol (HDL), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB), with 19.9% of the subjects presenting with apolipoprotein patterns similar to hypolipidemic clinical syndromes and 30% with either or both ApoA1 and ApoB less than the fifth centile. Subjects with levels less than the fifth centile of HDL or ApoA1 or ApoA1 + ApoB had lower adaptive functioning than other individuals with ASD, and hypocholesterolemic subjects had apolipoprotein deficits significantly divergent from either typically developing individuals participating in National Institutes of Health or the National Health and Nutrition Examination Survey III.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2158-3188
Relation: https://doaj.org/toc/2158-3188
DOI: 10.1038/s41398-021-01580-8
URL الوصول: https://doaj.org/article/b632fffbd72b4cc2b85b11e552267303
رقم الأكسشن: edsdoj.b632fffbd72b4cc2b85b11e552267303
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21583188
DOI:10.1038/s41398-021-01580-8