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The role of schizotypal traits and the OXTR gene in theory of mind in schizophrenia: A family-based study

التفاصيل البيبلوغرافية
العنوان: The role of schizotypal traits and the OXTR gene in theory of mind in schizophrenia: A family-based study
المؤلفون: M. Giralt-López, S. Miret, J. Soler, S. Campanera, M. Parellada, L. Fañanás, M. Fatjó-Vilas
المصدر: European Psychiatry, Vol 63 (2020)
بيانات النشر: Cambridge University Press, 2020.
سنة النشر: 2020
المجموعة: LCC:Psychiatry
مصطلحات موضوعية: Family-based study, OXTR gene, schizophrenia, schizotypy, theory of mind, Psychiatry, RC435-571
الوصف: AbstractBackground.There is consistent evidence that theory of mind (ToM) is impaired in schizophrenia (SZ); however, it remains unclear whether such deficits are trait- or state-dependent. We evaluated ToM in patients with schizophrenia spectrum disorders (SSDs), their healthy first-degree relatives, and controls to test its suitability as an endophenotypic marker. We also studied the modifying effect of markers of clinical and genetic liability to SZ (schizotypy and genetic variability in the oxytocin receptor gene: OXTR) on ToM in healthy individuals.Methods.The sample included 38 stable SSD patients, 80 unaffected first-degree relatives, and 81 controls. ToM was assessed using the Hinting Task (HT) and schizotypy via the Schizotypal Personality Questionnaire-Brief (SPQ-B), which generates interpersonal (SPQ-IP), cognitive-perceptual (SPQ-CP), and disorganization (SPQ-D) scores. The polymorphism rs53576 of OXTR was genotyped.Results.Patients presented poorer HT performance than relatives and controls (p = 0.003 and p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0924-9338
1778-3585
Relation: https://www.cambridge.org/core/product/identifier/S0924933819000178/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585
DOI: 10.1192/j.eurpsy.2019.17
URL الوصول: https://doaj.org/article/b6857f8b33424a62b7e83d4ac4cb3281
رقم الأكسشن: edsdoj.b6857f8b33424a62b7e83d4ac4cb3281
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09249338
17783585
DOI:10.1192/j.eurpsy.2019.17