دورية أكاديمية
Elevated small dense low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio is associated with an increased risk of metabolic dysfunction associated fatty liver disease in Chinese patients with type 2 diabetes mellitus
| العنوان: | Elevated small dense low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio is associated with an increased risk of metabolic dysfunction associated fatty liver disease in Chinese patients with type 2 diabetes mellitus |
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| المؤلفون: | Shouxing Yang, Jing Xu |
| المصدر: | Journal of Diabetes Investigation, Vol 15, Iss 5, Pp 634-642 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Metabolic dysfunction‐associated fatty liver diseases, Small dense low‐density lipoprotein cholesterol, Type 2 diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | ABSTRACT Introduction It is demonstrated that elevated small dense low‐density lipoprotein cholesterol (sdLDL‐C), and reduced high‐density lipoprotein cholesterol (HDL‐C) is associated with Metabolic dysfunction‐associated fatty liver disease (MAFLD). This study aims to explore the relationship between sdLDL‐C to HDL‐C ratio (SHR) and MAFLD in Chinese patients with type 2 diabetes mellitus (T2DM). Materials and Methods A cross‐sectional study was performed among 1904 patients with T2DM. Weighted multivariable logistic regression analysis was conducted to explore the relationship between the SHR and the risk of MAFLD. In addition, this study used a two‐part linear regression model to identify threshold effects. Subgroup analysis, interaction tests and receiver operating characteristic (ROC) curve analysis were also carried out. Results The overall MAFLD prevalence reached 48.1%. Multiple logistic regression analysis showed that SHR was positively correlated with the risk of MAFLD (OR = 2.37, 95% CI = 1.80–3.12). Subgroup analysis stratified by age, gender, hypertension and BMI showed that there was a consistent positive correlation. A non‐linear relationship and saturation effect between SHR and MAFLD risk were identified, with an inverted L shaped curve and an inflection point at 1.02. The area under the curve (AUC) for SHR in the ROC analysis was significantly greater than sdLDL‐C and HDL‐C, with a sensitivity of 71.2% and a specificity of 62.1%. Conclusions Elevated levels of SHR is independently associated with an increased risk of MAFLD in patients with T2DM. SHR may be taken as practical indicators to assess the risk of MAFLD in T2DM patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2040-1124 2040-1116 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.14148 |
| URL الوصول: | https://doaj.org/article/b6a6ebe4463548a1bf17b3aae6e692aa |
| رقم الأكسشن: | edsdoj.b6a6ebe4463548a1bf17b3aae6e692aa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.14148 |