دورية أكاديمية
Analysis of Oral Microbiota Revealed High Abundance of Prevotella Intermedia in Gout Patients
| العنوان: | Analysis of Oral Microbiota Revealed High Abundance of Prevotella Intermedia in Gout Patients |
|---|---|
| المؤلفون: | Juan Liu, Li Cui, Xinmin Yan, Xinyuan Zhao, Jinluo Cheng, Lei Zhou, Jianbo Gao, Zhong Cao, Xinhua Ye, Shen Hu |
| المصدر: | Cellular Physiology and Biochemistry, Vol 49, Iss 5, Pp 1804-1812 (2018) |
| بيانات النشر: | Cell Physiol Biochem Press GmbH & Co KG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Physiology LCC:Biochemistry |
| مصطلحات موضوعية: | Gout, Hyperuricemia, 16S rDNA sequencing, Oral microbiota, Prevotella intermedia, Streptococcus anginosus, Serratia marcescens, Physiology, QP1-981, Biochemistry, QD415-436 |
| الوصف: | Background/Aims: Microbes reside in a number of body sites, including the oral cavity, and are associated with the progression of many systemic diseases. In this study, we aimed to investigate the effects of gout and hyperuricemia (HUA) on the composition of oral microbiomes. Methods: Analysis of the oral microbiota from 12 gout patients, 11 HUA patients, and 19 healthy control subjects was performed using a deep sequencing approach, and validation of significant changes in Prevotella intermedia and Serratia marcescens in new patient cohorts was performed using quantitative PCR (qPCR). Results: Our analysis indicated that both gout and HUA significantly altered the composition of the oral microbiome in patients. Patients with gout or HUA had significantly greater levels of salivary Prevotella intermedia but significantly lower levels of Serratia marcescens than healthy control subjects. Conclusion: We demonstrated the association between the oral microbiome and gout and HUA for the first time. In particular, 16S sequencing and qPCR analysis revealed significantly higher levels of oral Prevotella intermedia in gout/HUA patients, which suggests that these patients might be at risk for the development of periodontitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1015-8987 1421-9778 |
| Relation: | https://www.karger.com/Article/FullText/493626; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778 |
| DOI: | 10.1159/000493626 |
| URL الوصول: | https://doaj.org/article/cb6a908590234d6ca9ce9887435ef578 |
| رقم الأكسشن: | edsdoj.b6a908590234d6ca9ce9887435ef578 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10158987 14219778 |
|---|---|
| DOI: | 10.1159/000493626 |