دورية أكاديمية
In vitro and in vivo dissolution of biocompatible S59 glass scaffolds
| العنوان: | In vitro and in vivo dissolution of biocompatible S59 glass scaffolds |
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| المؤلفون: | Laura Aalto-Setälä, Peter Uppstu, Robert Björkenheim, Gustav Strömberg, Nina C. Lindfors, Jukka Pajarinen, Leena Hupa |
| المصدر: | Journal of Materials Science: Materials in Medicine, Vol 35, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | Springer, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Medical technology |
| مصطلحات موضوعية: | Materials of engineering and construction. Mechanics of materials, TA401-492, Medical technology, R855-855.5 |
| الوصف: | Abstract Fabrication of porous tissue-engineering scaffolds from bioactive glasses (BAG) is complicated by the tendency of BAG compositions to crystallize in thermal treatments during scaffold manufacture. Here, experimental biocompatible glass S59 (SiO2 59.7 wt%, Na2O 25.5 wt%, CaO 11.0 wt%, P2O5 2.5 wt%, B2O3 1.3 wt%), known to be resistant to crystallization, was used in sintering of glass granules (300–500 µm) into porous scaffolds. The dissolution behavior of the scaffolds was then studied in vivo in rabbit femurs and under continuous flow conditions in vitro (14 days in vitro/56 days in vivo). The scaffolds were osteoconductive in vivo, as bone could grow into the scaffold structure. Still, the scaffolds could not induce sufficiently rapid bone ingrowth to replace the strength lost due to dissolution. The scaffolds lost their structure and strength as the scaffold necks dissolved. In vitro, S59 dissolved congruently throughout the 14-day experiments, resulting in only a slight reaction layer formation. Manufacturing BAG scaffolds from S59 that retain their amorphous structure was thus possible. The relatively rapid and stable dissolution of the scaffold implies that the glass S59 may have the potential to be used in composite implants providing initial strength and stable, predictable release of ions over longer exposure times. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1573-4838 |
| Relation: | https://doaj.org/toc/1573-4838 |
| DOI: | 10.1007/s10856-024-06795-x |
| URL الوصول: | https://doaj.org/article/ab6ae41617d14a7b9a24d30986dea35a |
| رقم الأكسشن: | edsdoj.b6ae41617d14a7b9a24d30986dea35a |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 15734838 |
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| DOI: | 10.1007/s10856-024-06795-x |