دورية أكاديمية
Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii.
| العنوان: | Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii. |
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| المؤلفون: | Xiao-Xuan Zhang, Yu-Zhe Sun, Wei Wang, Yang Gao, Xin-Yu Wei, Hong-Chao Sun, Chun-Ren Wang, Hong-Bo Ni, Xing Yang, Hany M Elsheikha, Huan-Ping Guo |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012281 (2024) |
| بيانات النشر: | Public Library of Science (PLoS), 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270 |
| الوصف: | BackgroundPathogens can impact host RNA modification machinery to establish a favorable cellular environment for their replication. In the present study, we investigated the effect of Toxoplasma gondii infection on host RNA modification profiles and explored how these modifications may influence the host-parasite interaction.Methodology/principal findingsWe analyzed the modification levels of ∼ 80 nt tRNA and 17-50 nt sncRNAs in mouse liver, spleen, and serum using liquid chromatography and tandem mass spectrometry analysis. The results revealed alterations in RNA modification profiles, particularly during acute infection. The liver exhibited more differentially abundant RNA modifications than the spleen. RNA modification levels in serum were mostly downregulated during acute infection compared to control mice. Correlations were detected between different RNA modifications in the liver and spleen during infection and between several RNA modifications and many cytokines. Alterations in RNA modifications affected tRNA stability and protein translation.Conclusions/significanceThese findings provide new insight into the role of RNA modifications in mediating the murine host response to T. gondii infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1935-2727 1935-2735 |
| Relation: | https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735 |
| DOI: | 10.1371/journal.pntd.0012281 |
| URL الوصول: | https://doaj.org/article/b6e94ac4455f4fe2beb2702602f4a7c3 |
| رقم الأكسشن: | edsdoj.b6e94ac4455f4fe2beb2702602f4a7c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19352727 19352735 |
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| DOI: | 10.1371/journal.pntd.0012281 |