دورية أكاديمية
Synthesis, Molecular Docking and Biological Properties of Novel Thiazolo[4,5-b]pyridine derivatives
| العنوان: | Synthesis, Molecular Docking and Biological Properties of Novel Thiazolo[4,5-b]pyridine derivatives |
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| المؤلفون: | Taras I. Chaban, Julia E. Matiychuk, Olga Ya. Shyyka, Ihor G. Chaban, Volodymyr V. Ogurtsov, Ihor A. Nektegayev, Vasyl S. Matiychuk |
| المصدر: | Acta Chimica Slovenica, Vol 67, Iss 4, Pp 1035-1043 (2020) |
| بيانات النشر: | Slovenian Chemical Society, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | organic synthesis, thiazolo[4,5-b]pyridin-2-ones, anti-inflammatory activity, antioxidant activity, molecular docking, Chemistry, QD1-999 |
| الوصف: | The synthesis, anti-inflammatory and antioxidant properties of novel 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one derivatives were discussed. Fused thiazolo[4,5-b]pyridin-2-ones were synthesized and modified at the N3, C5 and C6 positions of the main core in order to obtain the compounds with a satisfactory pharmacological profile. The synthesized compounds were preselected via molecular docking for further testing of their anti-inflammatory activity in vitro. Evaluation of novel compounds over the carageenin induced rat paw edema revealed strong anti-inflammatory action of some compounds including (thiazolo[4,5-b]pyridin-3(2H)-yl) propanenitrile (5) and thiazolo[4,5-b]pyridin-3(2H)-yl) propanoic acid (6) even exceeding the standard – Ibuprofen. The antioxidant activity of the synthesized compounds was measured in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1318-0207 1580-3155 |
| Relation: | https://journals.matheo.si/index.php/ACSi/article/view/5439; https://doaj.org/toc/1318-0207; https://doaj.org/toc/1580-3155 |
| DOI: | 10.17344/acsi.2019.5439 |
| URL الوصول: | https://doaj.org/article/b71c522e9d1840ed9efab919c4e2b4f0 |
| رقم الأكسشن: | edsdoj.b71c522e9d1840ed9efab919c4e2b4f0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13180207 15803155 |
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| DOI: | 10.17344/acsi.2019.5439 |