دورية أكاديمية
أعرض في EDS

CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.

التفاصيل البيبلوغرافية
العنوان: CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.
المؤلفون: Camille Lécuroux, Isabelle Girault, Antoine Chéret, Pierre Versmisse, Georges Nembot, Laurence Meyer, Christine Rouzioux, Gianfranco Pancino, Alain Venet, Asier Sáez-Cirión, ANRS 147 OPTIPRIM clinical trial
المصدر: PLoS ONE, Vol 8, Iss 3, p e59767 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3612088?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0059767
URL الوصول: https://doaj.org/article/b72e95dc3ebb4c479e1705fc8a890ba9
رقم الأكسشن: edsdoj.b72e95dc3ebb4c479e1705fc8a890ba9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0059767