دورية أكاديمية
CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.
العنوان: | CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. |
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المؤلفون: | Camille Lécuroux, Isabelle Girault, Antoine Chéret, Pierre Versmisse, Georges Nembot, Laurence Meyer, Christine Rouzioux, Gianfranco Pancino, Alain Venet, Asier Sáez-Cirión, ANRS 147 OPTIPRIM clinical trial |
المصدر: | PLoS ONE, Vol 8, Iss 3, p e59767 (2013) |
بيانات النشر: | Public Library of Science (PLoS), 2013. |
سنة النشر: | 2013 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | http://europepmc.org/articles/PMC3612088?pdf=render; https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0059767 |
URL الوصول: | https://doaj.org/article/b72e95dc3ebb4c479e1705fc8a890ba9 |
رقم الأكسشن: | edsdoj.b72e95dc3ebb4c479e1705fc8a890ba9 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
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DOI: | 10.1371/journal.pone.0059767 |