دورية أكاديمية
Antioxidant and antineoplastic activities of roots of Hibiscus sabdariffa Linn. Against Ehrlich ascites carcinoma cells
| العنوان: | Antioxidant and antineoplastic activities of roots of Hibiscus sabdariffa Linn. Against Ehrlich ascites carcinoma cells |
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| المؤلفون: | Rumana Yesmin Hasi, Hanif Ali, Majidul Islam, Rowshanul Habib, Mohammed A. Satter, Tanzima Yeasmin |
| المصدر: | Clinical Phytoscience, Vol 5, Iss 1, Pp 1-9 (2019) |
| بيانات النشر: | SpringerOpen, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Homeopathy |
| مصطلحات موضوعية: | Hibiscus sabdariffa, Root, Antioxidant, Anticancer, GC-MS analysis, Medicine, Homeopathy, RX1-681 |
| الوصف: | Abstract Background The goal of this study was to explore the inherent antioxidant and antineoplastic activities of methanolic extract of the roots of Hibiscus sabdariffa (MEHSR). Methods The dried coarse powder of roots of Hibiscus sabdariffa was subjected to methanolic extraction. Here in vitro methods were used to determine the various types of phytochemical content and antioxidant activity of MEHSR as well as its cytotoxic effect against Ehrlich ascites carcinoma (EAC) cells. In vivo, antineoplastic activity of MEHSR against EAC cells was also evaluated by determining the viable tumor cell count, survival time, body weight gain, hematological profiles of experimental mice along with observing morphological changes of EAC cells by fluorescence microscope. Analysis of the chemical composition of MEHSR was carried out using GC-MS. Results Total phenolic and flavonoid contents of MEHSR were found to be 143.36 and 82.81 mg/g of extract in terms of gallic acid and catechin equivalent, respectively. The MEHSR exhibited very good scavenging property on DPPH (IC50: 13.37 μg/mL) and ABTS (IC50: 18.88 μg/mL) radicals in respect to nitric oxide (IC50: 72.82 μg/mL) radical and lipid peroxidation (IC50: 75.78 μg/mL) inhibition. MEHSR was found to induce Ehrlich ascites carcinoma (EAC) cell death at a dose dependent fashion. At dose 10 mg/kg, MEHSR significantly inhibited tumor cell growth rate (62.24%; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2199-1197 |
| Relation: | https://doaj.org/toc/2199-1197 |
| DOI: | 10.1186/s40816-019-0147-6 |
| URL الوصول: | https://doaj.org/article/eb7839b8675048b1a40adccff5a40b1d |
| رقم الأكسشن: | edsdoj.b7839b8675048b1a40adccff5a40b1d |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21991197 |
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| DOI: | 10.1186/s40816-019-0147-6 |