دورية أكاديمية
Galacto-Oligosaccharide Alleviates Alcohol-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation
| العنوان: | Galacto-Oligosaccharide Alleviates Alcohol-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation |
|---|---|
| المؤلفون: | Shipeng Zhou, Qiuhua Tan, Bingjian Wen, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan Su |
| المصدر: | Metabolites, Vol 12, Iss 9, p 867 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | alcoholic liver disease (ALD), antioxidant, anti-inflammatory, galacto-oligosaccharide, hepatoprotective, Microbiology, QR1-502 |
| الوصف: | Alcoholic liver disease (ALD) is a primary cause of mortality and morbidity worldwide. Oxidative stress and inflammation are important pathogenic factors contributing to ALD. We investigated the protective mechanism of galacto-oligosaccharide (GOS) against ALD through their antioxidant and anti-inflammatory activities by performing in vivo and in vitro experiments. Western blot and RT‒PCR results indicated that the expression of cytochrome P450 protein 2E1 (CYP2E1) in liver tissues and L02 cells was reduced in the GOS-treated mice compared with the model group. In addition, GOS prominently reduced the expression of Kelch-like ECH-associated protein 1 (Keap1), increased the expression of the nuclear factor erythroid-2-related factor 2 (Nrf2) and haem oxygenase-1 (HO-1) proteins, and enhanced the antioxidant capacity. In addition, GOS decreased inflammation by reducing inflammatory factor levels and inhibiting the mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-κB) pathway. Based on these results, GOS may be a prospective functional food for the prevention and treatment of ALD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12090867 2218-1989 |
| Relation: | https://www.mdpi.com/2218-1989/12/9/867; https://doaj.org/toc/2218-1989 |
| DOI: | 10.3390/metabo12090867 |
| URL الوصول: | https://doaj.org/article/cb7c10cd4e3548a5a23a353255d37b98 |
| رقم الأكسشن: | edsdoj.b7c10cd4e3548a5a23a353255d37b98 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12090867 22181989 |
|---|---|
| DOI: | 10.3390/metabo12090867 |