The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

التفاصيل البيبلوغرافية
العنوان:	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
المؤلفون:	Man Shang, Huijie Yang, Ran Yang, Tao Chen, Yuan Fu, Yeyi Li, Xianlong Fang, Kangjian Zhang, Jianju Zhang, Hui Li, Xueping Cao, Jinfa Gu, Jianwen Xiao, Qi Zhang, Xinyuan Liu, Qiujing Yu, Ting Wang
المصدر:	Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
بيانات النشر:	Nature Portfolio, 2021.
سنة النشر:	2021
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Metabolites have been reported not only to support the highly-demanding energetic needs of cancer cells but also as signalling regulators. Here, the authors show that the activity of the folate cycle enzyme MTHFD2 stimulates PD-L1 expression impairing T cell-mediated cytotoxicity and promoting tumourigenesis.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-021-22173-5
URL الوصول:	https://doaj.org/article/b7caa2a1cda04d89abb70680d3147f73
رقم الأكسشن:	edsdoj.b7caa2a1cda04d89abb70680d3147f73
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-021-22173-5