دورية أكاديمية
HCV-infected Renal Transplant Recipients: Our Experience before the Availability of New Antiviral Drugs
| العنوان: | HCV-infected Renal Transplant Recipients: Our Experience before the Availability of New Antiviral Drugs |
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| المؤلفون: | AR Fernandes, IJ Laranjinha, R Birne, P Matias, C Jorge, T Adrag�o, M Bruges, A Weigert, D Machado |
| المصدر: | International Journal of Organ Transplantation Medicine, Vol 8, Iss 2 (2017) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Hepatitis C, Kidney transplantation, Graft rejection, Survival Rate, Transplant recipients, Postoperative complications, Medicine |
| الوصف: | Background: Natural history of HCV-infected renal transplant recipients is about to change with the invention of new drugs available for the treatment of HCV. Objective: To analyze the evolution of renal transplant recipients infected with HCV in 30 years of activity of a Renal Transplantation Unit. Methods: We studied 1334 patients who underwent renal transplantation between 1985 and 2015. Results: 189 (14.2%) of these 1334 were found HCV seropositive. 60 were HCV RNA-positive for >6 months. 5 died with a functioning graft; 19 lost their graft and resumed dialysis. Most of the rejections occurred within the first year of the transplantation and none resulted in immediate loss of the graft. In post-transplantation period, 14 patients developed clinical hepatic disease, 10 manifested new-onset diabetes after transplantation, and 4 had de novo neoplasia, none of them had hepatocellular carcinoma. The outcomes of the different variables analyzed were similar between patients with HCV-infection and those with HCV and HBV co-infection. The median survival time was 13.4 (95% CI: 10.7–16.1) years; the median survival time of patients without HCV infection was 14.6 (95% CI: 13.8–15.4) years (p=0.23). Conclusion: In the era before the availability of new anti-HCV drugs, our experience with HCV-infected renal transplant recipients revealed similar post-transplantation complications, graft and patient survival as those not infected with HCV. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-6482 2008-6490 |
| Relation: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/398; https://doaj.org/toc/2008-6482; https://doaj.org/toc/2008-6490 |
| URL الوصول: | https://doaj.org/article/b82dcfdfe5e849739b25b02f58e246b1 |
| رقم الأكسشن: | edsdoj.b82dcfdfe5e849739b25b02f58e246b1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20086482 20086490 |
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