دورية أكاديمية
Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ
| العنوان: | Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ |
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| المؤلفون: | Qianqian Wu, Runjiao Yang, Wenxuan Fan, Li Wang, Jing Zhan, Tingting Cao, Qiming Liu, Xianshu Piao, Yinghui Zhong, Wenxian Zhao, Shuhan Zhang, Jiaao Yu, Song Liang, Thomas M. Roberts, Bingdi Wang, Zhenning Liu |
| المصدر: | Advanced Science, Vol 11, Iss 22, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | biomaterials, hydrogel, spermidine, inflammation, wound healing, Science |
| الوصف: | Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) is developed, where the first and second networks are formed by dynamic imine bonds and non‐dynamic photo‐crosslinked bonds respectively. The single network hydrogel before photo‐crosslinking exhibits excellent injectability and thus can be printed and photo‐crosslinked in situ to form double network hydrogels. DN‐SPD hydrogel has demonstrated desirable mechanical properties and tissue adhesion. More importantly, an “operando” comparison of hydrogels loaded with spermidine or diethylenetriamine (DETA), a sham molecule resembling spermidine, has shown similar physical properties, but quite different biological functions. Specifically, the outcomes of 3 sets of in vivo animal experiments demonstrate that DN‐SPD hydrogel can not only reduce inflammation caused by implanted exogenous biomaterials and reactive oxygen species but also promote the polarization of macrophages toward regenerative M2 phenotype, in comparison with DN‐DETA hydrogel. Moreover, the immunoregulation by spermidine can also translate into faster and more natural healing of both acute wounds and diabetic wounds. Hence, the local administration of spermidine affords a simple but elegant approach to attenuate foreign body reactions induced by exogenous biomaterials to treat chronic refractory wounds. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2198-3844 20231016 |
| Relation: | https://doaj.org/toc/2198-3844 |
| DOI: | 10.1002/advs.202310162 |
| URL الوصول: | https://doaj.org/article/aab8337e89d34a47820c7b956bba162d |
| رقم الأكسشن: | edsdoj.b8337e89d34a47820c7b956bba162d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21983844 20231016 |
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| DOI: | 10.1002/advs.202310162 |